We are conducting research on elucidation of toxic effects of environmental pollutants and its response mechanism mainly for cnidarians (corals), crustaceans (ami), fish (medaka), (aquatic) mammals, etc. Specifically, we evaluate in silico and in vitro systems, effects of endogenous endocrine systems (estrogen receptor, androgen receptor, etc.) and lipid metabolism system (peroxisome proliferator-responsive receptor) etc. on nuclear receptor signaling system of each organism species, then the influence on phenotype, the difference between organism species and the susceptibility factor are clarified. In order to understand the mechanism of toxicity of environmental pollutants at a molecular level, we promoted a research using DNA microarrays and genetic expression analysis such as next-generation sequences, bioinformatics, cell-free protein expression system, computational toxicology etc. The results of this research will become an important basic data in environmental risk assessment of environmental pollutants, identification of novel biomarker candidate genes is expected, in addition to elucidating the mechanism of toxicity development of environmental pollutants.

Related academic papers

Ishibashi et al., J. Appl. Toxicol. 1392-1400, 2016.

Uchida, Ishibashi et al., Ecotoxicol. Environ. Saf. 133, 360-365, 2016.

Ogino, Ishibashi et al., Mol. Biol. Evol. 33, 228-244, 2015.

Tohyama, Ishibashi et al., Environ. Sci. Technol. 49, 7439-7447, 2015.

Miyagawa, Ishibashi et al., Endocrinology 156, 2795-2806, 2015.

Yamaguchi, Ishibashi et al., Ecotoxicol Environ. Saf. 120, 198-205, 2015.

Uchida, Ishibashi et al., J. Appl. Toxicol. 35, 1040-1048, 2015.

Hiroshi Ishibashi: 13.6 Endocrine disrupter chemical (Environmental hormone). Science of Health and Environment, Kodansha,145-151. 2014 (in Japanese).

Ishibashi et al., Environ. Sci. Technol. 45, 3123-3130, 2011.

Related Scientific Research Grants

FY 2016 - 2019 (Principle Researcher): Fundamental Research (B) "Comparative biological risk assessment of PPARα signaling disturbance by New POPs"

FY 2016 - 2018 (Member Researcher): Fundamental Research (B) "Improvement of eco-toxicological test of Medaka embryonic stage by high-electric field pulsed substance introduction method"

FY 2016 (Member Researcher): Fundamental Research (B) "Construction of a new chemical risk assessment system for basic producers using coral and large seaweeds "

FY 2012 - 2014 (Principle Researcher): Fundamental Research (B) "High-throughput risk assessment of brominated flame retardants using nuclear receptors PPARα"

FY 2013 - 2014 (Principle Researcher): Challenging Sprout Research, "simultaneous screening analysis of estrogenic actions of PPCPs"
2009 - 2013 (Member Researcher): Fundamental Research (S), "Elucidation of susceptibility-controlling factors of intracellular receptors by chemical substances-foreign body metabolizing enzyme signal transduction system disturbance"

Off-campus position on industry-government-academia collaboration:

2015- at present (Secretary): Japan Society on Water Environment Chūgoku-Shikoku branch

2012-at present (Board member): Biochemical Assay Society of Japan

2017-2018 Working Group Committee of Japanese Industrial Standards [JIS], (General rules of immunoassay of polychlorobiphenyl).